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目的:观察威灵仙总皂苷对佐剂性关节炎(AA)大鼠踝关节病理改变的影响。方法:大鼠足趾皮内注射弗氏完全佐剂致佐剂性关节炎,威灵仙总皂苷按25、50、100 mg/kg剂量灌胃给药15天,观察大鼠踝关节滑膜、关节腔、软骨、周围软组织等组织病理情况。结果:威灵仙总皂苷(50、100 mg/kg)明显减轻AA大鼠踝关节病理损伤。结论:威灵仙总皂苷可改善AA大鼠的踝关节组织病理改变。
Objective: To observe the effect of Clematis total saponin on pathological changes of ankle in adjuvant arthritis (AA) rats. Methods: Freund’s complete adjuvant induced adjuvant arthritis was injected intradermally in foot toe of rats. Total clematis total saponin was administered intragastrically at 25, 50 and 100 mg / kg for 15 days. The ankle synovial membrane , Joint cavity, cartilage, surrounding soft tissue histopathology. Results: Clematis total saponins (50, 100 mg / kg) significantly reduced the ankle injury in AA rats. Conclusion: Clematis total saponin can improve pathological changes of ankle in AA rats.