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蛋白酶体作为蛋白酶家族中一个复杂成员,在真核细胞、古细菌和一些真细菌中均有发现。真核细胞蛋白酶体在蛋白质质量控制和细胞稳态维持中起关键作用,同时涉及多种细胞活动,包括细胞周期运行和抗原提呈等。对真核细胞蛋白酶体在疾病治疗中的作用机制和相关靶点药物的研发已引起了广泛关注。该文综述了真核细胞蛋白酶体结构与功能相关的研究进展,重点阐述了不同形式20S核心颗粒(20S core partical,20S CP)和不同种类调节颗粒间的相互作用。
Proteasome, a complex member of the protease family, has been found in eukaryotes, archaebacteria, and some eubacteria. Eukaryotic cell proteasome plays a key role in the control of protein quality and maintenance of cell homeostasis, as well as in a variety of cell activities including cell cycle arrest and antigen presentation. Eucaryotic proteasomes in the treatment of disease mechanisms and related target drug development has attracted widespread attention. This review summarizes the recent advances in the study of the structure and function of proteasomes in eukaryotes, highlighting the interactions between different forms of 20S core (20S CP) and different regulatory molecules.