论文部分内容阅读
目的对近年来关于内源性大麻素系统在肝脏疾病中的作用及相关机制的研究做整理分析。方法查阅近年来的国内外文献,进行全面综合、整理和归纳。结果综述了内源性大麻素在肝病发生发展中的重要作用,重点阐述了其在病毒性肝炎、酒精性脂肪肝、非酒精性脂肪肝病、胆汁淤积性肝病及肝脏缺血再灌注损伤中的预防与保护作用以及调控肝纤维化的发生发展及肝病并发症肝性脑病的发病过程。结论内源性大麻素系统在肝病的治疗中具有重要作用,但作用机制复杂,亟待更深入的研究。
Objective To analyze and analyze the role of endocannabinoid system in liver diseases in recent years and related mechanisms. Methods Access to domestic and foreign literature in recent years, a comprehensive, collated and summarized. The results summarize the important role of endocannabinoids in the development of liver diseases, and mainly focus on its role in viral hepatitis, alcoholic fatty liver disease, non-alcoholic fatty liver disease, cholestatic liver disease and liver ischemia-reperfusion injury Prevention and protection as well as regulating the occurrence and development of hepatic fibrosis and liver disease complications of hepatic encephalopathy pathogenesis. Conclusion The endocannabinoid system plays an important role in the treatment of liver disease, but the mechanism of action is complex and needs further study.