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目的评价成都市甲型H1N1流感疫苗接种1年后疫苗免疫持久性。方法以2010年免后1个月H I抗体≥1∶40的398人作为观察对象,用微量血凝抑制试验方法测定抗体,计算人群抗体几何平均滴度(GMT)和疫苗保护率。结果免疫后1年人群GMT下降62.03%,抗体保护率达92.71%,老年组保护率为83.12%;免后1个月低抗体水平个体(1∶40、1∶80),1年后有40.21%的人抗体滴度上升。结论甲流疫苗具有一定的免疫持久性,老人免疫持久性相对较差。
Objective To evaluate the vaccine immunization durability of the H1N1 influenza vaccine in Chengdu one year after inoculation. Methods Using 398 human H I antibody ≥1:40 one month after immunization in 2010 as the observation object, the antibody was measured by the microagglutination inhibition test and the geometric mean antibody titer (GMT) and vaccine protection rate were calculated. Results One year after immunization, the GMT decreased 62.03%, the antibody protection rate reached 92.71%, and the protection rate in the elderly group was 83.12%. One month after immunization, the GMT was lower in individuals with low antibody level (1:40, 1:80) and 40.21 % Of human antibody titers increased. Conclusion Influenza A vaccine has a certain immune persistence, the elderly immune persistence is relatively poor.