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目的 研究脊髓损伤后神经性疼痛差异化形成的行为学特点.方法 30只大鼠建立脊髓损伤模型,通过BBB运动行为学方法 测评脊髓损伤后运动功能,＞12分动物入选.对入选动物采用“Up-Down”疼痛行为学方法 评估脊髓损伤后疼痛,并根据形成情况,将大鼠分为观察组和对照组,计算脊髓损伤后疼痛形成比率,及二组大鼠的疼痛行为学特点.结果 5只大鼠死亡,1只大鼠在术后3d内BBB评分＞1分,7只大鼠在建模后2周时BBB评分＜12分,共13只大鼠被排除,其余17只大鼠入选.二组大鼠各时间点运动评分比较,差异无统计学意义(P＞0.05).在建立脊髓模型2周后,形成疼痛的动物数量逐渐增加,在建模4周时,8只大鼠形成疼痛,9只大鼠未形成疼痛,疼痛形成发生率为47.1％.与建模前比较,建模后4周时观察组大鼠的双侧足回缩阈值明显降低(P＜0.05);与对照组比较,建模后4周时观察组大鼠的双侧足回缩阈值也明显降低(P＜0.05).结论 脊髓损伤后2周疼痛逐渐形成,在4周时有近50％的大鼠形成了脊髓损伤后疼痛,模拟了临床脊髓损伤后疼痛形成特点.“,”Objective To investigate the differentiated formation of neuropathic pain after spinal cord injury(SCI) in rats. Methods SCI model was established in thirty rats, and BBB scale was performed to evaluate the body activity ability, and the animals above 12 on BBB scale were recruited to assess neuropathic pain after SCI using “Up - Down” method, and the animals were divided into pain group and No- pain group. The ratio of animals suffered from neuropathic pain after SCI was calculated. Results After SCI model was established, 5 animals were dead, the BBB scale was above 1 in one rat on the third day and was below 12 in seven animals on the second weeks, and all of these animals were excluded. The total number of seventeen animals was chosen. Three animals formed pain on the 2nd weeks after SCI, seven on the 3rd weeks, and final eight animals formed neuropathic pain on the 4th weeks after SCI, and the ratio was 47. 1 percent. Compared to baseline, paw withdrawal threshold at the fourth week decreased significantly in animals in pain group (P＜0. 05). Compared to animals in No- pain group, paw withdrawal threshold significantly reduced in animals of pain group (P＜ 0. 05). Conclusion Pain forms at two weeks after SCI, and increased cross time, nearly 50 percent animals form neuropathic pain on the 4th weeks, and the model mimics the differentiated formation of neuropathic pain after SCI.