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目的 探索内蒙籍蒙古族儿童HLA DRB1等位基因对过敏性紫癜 (AP)的遗传易感性。方法 采用PCR SSP技术 ,在祖籍三代居住内蒙地区蒙古族人群中 ,选择 5 7例儿童AP和 10 2例健康儿童 ,作以HLA DRB1等位基因的型别分析。结果 病例组DRB1 110x等位基因频率为 13 2 % ,明显高于对照组6 1% ,差异有显著意义 (χ2 =4 378,P =0 0 36 <0 0 5 )。并得出RR =2 386 >1,其 95 %可信区间为 1 0 4 5～5 4 4 7,其内不包含 1,与P值意义相符 ,既有统计学意义 ,又有实际意义。EF =0 14 3>0。结论 HLA DRB1 110x等位基因可能是内蒙籍蒙古族儿童AP发病单体型中一个遗传易感基因。
Objective To explore the genetic susceptibility of allergic purpura (AP) to HLA DRB1 alleles in Inner Mongolian and Mongolian children. Methods PCR SSP technique was used to select 57 ethnic children and 102 healthy children from three generations living in Mongolian nationality in Inner Mongolia for the HLA DRB1 allele type analysis. Results The frequency of allele DRB1 110x was 132% in case group, which was significantly higher than 61% in control group (χ2 = 4 378, P = 0 36 <0 05). The result shows that RR = 2 386> 1, 95% confidence interval is 1 045 ~ 5447, which does not include 1, which is consistent with the significance of P value, which is of both statistical significance and practical significance. EF = 0 14 3> 0. Conclusion The HLA DRB1 110x allele may be a genetic predisposition to AP haplotype in Mongolian children in Inner Mongolia and Inner Mongolia.