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目的探讨肺部良性疾病对乏氧组织显像剂99Tcm-4,9-二氮-3,3,10,10-四甲基十二烷-2,11-二酮肟(HL91)的摄取特点,以提高对肺癌诊断的特异性。方法32例肺部良性疾病患者在静脉注射99Tcm-HL91 1110 MBq后1h(早期相)及4 h(延迟相)进行平面显像,根据显像进行目测和半定量分析[计算病灶与对侧正常肺组织摄取99Tcm-HL91的放射性计数比值(T/N)],并同时获得4 h T/N与1 h T/N之相对比值(RR)。结果肺部良性疾病对99Tcm-HL91摄取表现为3种类型:(1)早期相及延迟相显像均未见异常放射性摄取,前后T/N值相比无统计学差异(1.10±0.01与1.09±0.01,n=14,t=1.87,P(0.05)。(2)病灶对99Tcm-HL91表现为早期相明显摄取及延迟相无明显清除,前后T/N值相比无统计学差异(1.46±0.33与1.50±0.37,n=13,t=0.29,P(0.05)。(3)病灶对99Tcm-HL91表现为早期相明显摄取及延迟相明显清除,前后T/N值相比有统计学差异(1.43±0.22与1.11±0.19,n=5,t=2.46,P<0.05)。3种类型的RR值分别为1.01±0.01、1.12±0.10、0.90±0.11,均<1.25。结论肺部良性疾病对99Tcm-HL91的摄取具有多样性,熟悉这些多样性,并结合半定量分析技术,尤其是RR值,有助于提高对肺癌诊断的特异性。
Objective To investigate the uptake of 99Tcm-4,9-diazonia-3,3,10,10-tetramethyldodecane-2,11-dione oxime (HL91) , In order to improve the diagnosis of lung cancer specificity. Methods Thirty-two patients with benign pulmonary disease underwent planar imaging at 1 h (early phase) and 4 h (delayed phase) after intravenous injection of 991 cm-HL91 at 1110 MBq. Visual and semi-quantitative analysis was performed according to imaging [ (T / N) ratio of uptake of 99Tcm-HL91 in lung tissue], and the relative ratio (RR) of 4 h T / N to 1 h T / N was also obtained. Results There were 3 types of uptake of 99Tcm-HL91 in benign lung diseases: (1) No abnormal radioactive uptake was observed in early phase and delayed phase imaging, and there was no significant difference in T / N ratio between before and after treatment (1.10 ± 0.01 vs. 1.09 ± 0.01, n = 14, t = 1.87, P (0.05). (2) There was no significant difference in the 99Tcm-HL91 uptake and delayed phase in 99Tcm-HL91 ± 0.33 and 1.50 ± 0.37, n = 13, t = 0.29, P (0.05). (3) The lesions showed obvious uptake of 99Tcm-HL91 and clear phase of delayed phase, T / N ratio was statistically significant (1.43 ± 0.22 vs 1.11 ± 0.19, n = 5, t = 2.46, P <0.05). The RR of the three types were 1.01 ± 0.01, 1.12 ± 0.10 and 0.90 ± 0.11, The diversity of 99Tcm-HL91 uptake in benign diseases is familiar, familiarity with these diversity, and combined with semi-quantitative analysis techniques, especially the RR value, can help to improve the specificity of diagnosis of lung cancer.