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自身反应细胞克隆缺失及功能灭活涉及T 细胞在胸腺内分化发育机理,这些机理对成熟后发生耐受至关重要,但它的发生系外周T 细胞对自身还是外源抗原所致尚未清楚。据此,本文研究BALB/c 小鼠静注金葡菌肠毒素B(SEB)诱导胸腺外耐受后,带Vβ8 TcR 的CD_4~+或CD_8~+T 细胞数目变化。注射SEB 前,脾内上述二类细胞分别为20%,30%;注射SEB 后4天在CD_4~+及CD_8~+T 细胞中Vβ8.1.2~+细胞出现率增加1.5倍;7天后Vβ8.1.2~+CD_4~+细胞降低到10%,而Vβ8.1.2~+CD_8~+细胞则回复至注射前水平;
Deletion and functional inactivation of self-reactive cell clones involve in the development and differentiation of T cells in the thymus. These mechanisms are crucial for the development of tolerance after maturation. However, it is unclear whether peripheral T cells are themselves or exogenous antigens. In this study, we investigated the changes of CD_4 ~ + or CD_8 ~ + T cells with Vβ8 TcR in BALB / c mice induced by Staphylococcus aureus enterotoxin B (SEB). Before SEB injection, the above two types of cells in the spleen were 20% and 30%, respectively. The incidence of Vβ8.1.2 ~ + cells in CD 4+ and CD_8 + T cells increased 1.5 times 4 days after SEB injection and Vβ8 after 7 days. 1.2 ~ + CD_4 ~ + cells decreased to 10%, while Vβ8.1.2 ~ + CD_8 ~ + cells returned to pre-injection levels;