前言:1976年Wilken最先提出同型半胱氨酸(Hcy)是心血管疾病的独立危险因素,随后许多研究相继证实了Hcy与急性心肌梗死[1]、脑卒中[2]、冠状动脉病变[3]以及外周血管病变[4]的关系。研究表明HCY作为一种炎症刺激物,通过多种途径促发炎症反应,启动由细胞免疫所介导的局部和全身慢性炎症,参与了病理性血管损伤的发生和发展。 Preamble: Wilken first proposed in 1976 that homocysteine ​​(Hcy) is an independent risk factor for cardiovascular disease, followed by many studies have confirmed Hcy and acute myocardial infarction [1], stroke [2], coronary lesions [ 3] and peripheral vascular disease [4] relationship. Studies have shown that HCY as an inflammatory stimulus, through a variety of ways to promote the inflammatory response, start by the cellular immunity-mediated local and systemic chronic inflammation, involved in the pathogenesis of vascular injury and development.