论文部分内容阅读
目的了解长汀县国家耐药监测点耐药结核病流行状态。方法根据《全国结核病耐药性基线调查实施手册》的患者纳入原则,2013—2015年长汀县CDC结核病防治门诊连续纳入涂阳肺结核患者158例,对患者痰标本分离培养获得的152株阳性菌株进行9种药物(一线:H、R、S、E;二线:K、O、C、P、TH1321)药敏试验和对硝基苯甲酸Mtb菌型鉴定。结果监测3年结核分枝杆菌总耐药率23.0%,总耐多药率3.3%,总广泛耐药率为0.7%。总耐药率低于全国平均水平,与福建省平均水平类似,总耐多药率均低于国家和福建省平均水平。结论长汀县的结核病控制策略执行得力,对于广泛耐药结核病,将在监测中予以重点关注,以控制结核病耐药趋势。
Objective To understand the prevalence of drug-resistant tuberculosis in national drug-resistant surveillance sites in Changting County. Methods According to the principle of patient inclusion in the National Tuberculosis Drug Resistance Baseline Survey Implementation Manual, from 2013 to 2015, CDT tuberculosis prevention and treatment clinics in Changting County were consecutively enrolled in 158 smear positive pulmonary tuberculosis patients. 152 positive strains isolated from sputum samples Drug susceptibility testing and identification of p-nitrobenzoate Mtb were performed on nine drugs (first line: H, R, S, E; second line: K, O, C, P, TH1321) Results The total drug resistance rate of Mycobacterium tuberculosis in three years was 23.0%, the total MDR rate was 3.3% and the total drug resistance rate was 0.7%. The total drug resistance rate is lower than the national average, which is similar to the average level in Fujian Province, and the total MDR rates are lower than the average level of the state and Fujian Province. Conclusions The control strategy for tuberculosis in Changting County is effective. For extensively drug-resistant tuberculosis, we will focus our attention on monitoring to control the trend of drug-resistant TB.