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目的:探讨血管紧张素转换酶(angiotensin 1-converting enzyme,ACE)基因、纤溶酶原激活物抑制物-1(plasminogen activator inhibitor-1,PAI-1)基因多态性与2型糖尿病(type 2 diabetes,T2DM)患者冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)的关系。方法:对100例单纯T2DM患者、60例T2DM合并冠心病患者进行ACE基因、PAI-1基因多态性检测,比较两组患者基因型及等位基因分布频率的差异;并进行Logistic多元回归分析影响T2DM患者冠心病的危险因素。结果:冠心病组患者PAI-1基因型频率、4G等位基因频率携带者比例较单纯T2DM患者显著增高(P<0.05)Logistic多元回归分析发现冠心病和PAI-1基因型密切相关。结论:PAI-1基因多态性可能是T2DM患者合并冠心病的危险因素。
Objective: To investigate the relationship between angiotensin 1-converting enzyme (ACE) gene, plasminogen activator inhibitor-1 (PAI-1) gene polymorphism and type 2 diabetes mellitus 2 diabetes mellitus (T2DM) patients with coronary heart disease (CHD). Methods: The polymorphisms of ACE gene and PAI-1 in 60 patients with T2DM complicated with coronary heart disease were detected in 100 patients with simple T2DM. The differences of genotype and allele frequencies between the two groups were compared. Logistic multiple regression analysis Risk factors for coronary heart disease in patients with T2DM. Results: The prevalence of PAI-1 genotype and 4G allele in CHD patients was significantly higher than that in T2DM patients (P <0.05). Logistic regression analysis showed that there was a close correlation between CHD and PAI-1 genotypes. Conclusion: PAI-1 gene polymorphism may be a risk factor for coronary heart disease in T2DM patients.