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目的:探讨外周血Th17细胞、Tc17细胞在支气管哮喘患者中的表达及临床意义。方法:选取37例轻度和23例中重度急性支气管哮喘患者及26例哮喘缓解患者作为研究对象,采用流式细胞术检测Th17细胞及Tc17细胞百分率、Treg细胞的百分率,ELISA方法测定IL-17的表达。结果:轻度、中重度急性哮喘组外周血中Th17及Tc17细胞百分率,IL-17的含量均高于缓解组及正常对照组(P<0.01),中重度哮喘组高于轻度哮喘组(P<0.01)。Tc17细胞在治疗缓解组中表达高于正常对照组(P<0.01)。结论:Tc17细胞及Th17/Tc17联合检测可能成为哮喘发作期的检测指标,并有望为哮喘的治疗提供新的靶点。
Objective: To investigate the expression and clinical significance of Th17 cells and Tc17 cells in patients with bronchial asthma. Methods: Thirty-seven patients with mild and 23 moderate-severe acute asthma and 26 patients with asthma were selected as research objects. The percentage of Th17 cells, Tc17 cells and Treg cells were determined by flow cytometry. The levels of IL-17 expression. Results: The percentage of Th17 and Tc17 cells and the content of IL-17 in peripheral blood of mild and moderate acute asthma group were higher than that of remission group and normal control group (P <0.01), moderate and severe asthma group was higher than mild asthma group P <0.01). The expression of Tc17 in treatment remission group was higher than that in normal control group (P <0.01). Conclusion: The combination of Tc17 cells and Th17 / Tc17 detection may be the detection target of asthma attack and it is expected to provide a new target for the treatment of asthma.