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目的探讨乙型肝炎在患者及其子女间的遗传传递。方法对乙型肝炎患者３５个家系７４个个体，进行了血清游离型和外周血单核细胞内整合型ＨＢＶＤＮＡＵ５样序列片段和单链ＤＮＡ构象多态性等指标检测。结果男性患者及其病后出生的子女Ｕ５样序列检出率均显著高于其病前出生子女，差异有显著性；Ｕ５样序列检出率在乙型肝炎患者和该患者病后出生的子女呈一致性增高，可具有完全一致的单链泳动变位。男性患者病后出生子女的ＨＢｓＡｇ、ＨＢｅＡｇ、抗－ＨＢｃ阳性率和感染率均分别显著高于其病前出生子女，差异有显著性；男性患者的ＨＢｓＡｇ、ＨＢｅＡｇ、抗－ＨＢｃ阳性率与其病后出生子女呈一致性增高。结论从分子遗传学水平为乙型肝炎的遗传传递学说提供了证据。
Objective To investigate the hereditary transmission of hepatitis B between patients and their children. Methods Totally 74 individuals from 35 pedigrees of hepatitis B patients were enrolled in this study. The detection of conformational polymorphisms of HBVDNAU5-like sequences and single-stranded DNA in serum-free and peripheral blood mononuclear cells were performed. Results The detection rate of U5-like sequences in male patients and their children born after the illness was significantly higher than that of the children born before the illness, the difference was significant; the detection rate of U5-like sequence was significantly higher in patients with hepatitis B and those born after the illness Consistent with increased, can have exactly the same single-chain electrophoresis. The positive rates of HBsAg, HBeAg, anti-HBc and the prevalence of HBsAg, HBeAg and anti-HBc in male patients were significantly higher than those in their pre-birth children, respectively. The positive rates of HBsAg, HBeAg and anti-HBc in male patients were Birth children are consistently higher. Conclusion The evidence from the molecular genetics level for the hereditary transmission of hepatitis B is provided.