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目的分析某院1 286株临床常见病原菌的分布及耐药状况。方法对该院2014-2015年分离病原菌进行回顾性分析。采用珠海黑马微生物鉴定产品进行细菌鉴定及药敏试验,应用WHONET 5.4软件对数据进行分析处理。结果分离1 286株病原菌中革兰阳性菌,404株,占31.42%;革兰阴性菌791株,占61.51%;真菌91株,占7.08%。各病原菌呈现出不同程度耐药性,鲍曼不动杆菌对多种药物呈现高耐药率。未检出万古霉素、利奈唑胺中介和耐药的革兰阳性球菌。结论分离病原菌中以革兰阴性杆菌为主,其次是革兰阳性球菌,除鲍曼不动杆菌外其他病原菌2年内无分离率大的变化,各类病原菌表现出不同程度耐药性。做好细菌耐药检测工作,指导临床合理使用抗生素,减少耐药菌的产生。
Objective To analyze the distribution and drug resistance of 1 286 clinical pathogens in a hospital. Methods A retrospective analysis of pathogenic bacteria isolated from the hospital from 2014 to 2015 was conducted. Using Zhuhai dark horse microbial identification products for bacterial identification and drug susceptibility testing, the application of WHONET 5.4 software for data analysis and processing. Results There were 404 strains of Gram-positive bacteria in 1 286 strains of pathogens, accounting for 31.42%; 791 strains of Gram-negative bacteria, accounting for 61.51%; 91 strains of fungi, accounting for 7.08%. The pathogens showed different degrees of resistance, Acinetobacter baumanii showed a high rate of resistance to a variety of drugs. No vancomycin, linezolid mediators and resistant Gram-positive cocci were detected. Conclusion Gram-negative bacilli were the main pathogens in the isolates, followed by Gram-positive cocci. There were no significant changes in other pathogens except Acinetobacter baumannii within 2 years, and all kinds of pathogens showed different degrees of resistance. Bacterial drug resistance testing done to guide the clinical rational use of antibiotics to reduce the generation of resistant bacteria.