多发性硬化症(MS)的表达蛋白组学研究成果为MS的诊断和预防提供了新途径。针对血清以及脑脊液的样品制备,蛋白质离析与鉴定方法得到了改进,更多MS的诊断标志和新药标靶也逐步被人们发现。同时,蛋白微阵列新技术的应用有助于确定自身免疫疾病潜在的自身抗体和相关的自身抗原,并且增强对治疗反应的检测。而人脑蛋白组图谱与蛋白质数据库的逐步完善为针对MS疾病治疗的系统研究奠定了基础。 Multiple sclerosis (MS) expression Proteomics research results provide a new way for the diagnosis and prevention of MS. The methods of sample preparation, protein isolation and identification for serum and cerebrospinal fluid have been improved. More and more MS diagnostic markers and new drug targets have also been gradually discovered. At the same time, the use of new protein microarray technologies helps identify potential autoantibodies and associated autoantigens in autoimmune diseases and enhances the detection of response to treatment. The gradual improvement of human brain proteome map and protein database laid the foundation for the systematic study of MS disease treatment.