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脓毒症是机体对感染的反应失调而导致危及生命的器官功能障碍，肾脏是脓毒症最常累及的器官之一，脓毒症急性肾损伤发病率高、死亡率高。随着研究的不断深入，关于脓毒症急性肾损伤的早期识别、发病机制、诊疗的研究逐年增多，本文整理相关文献，从脓毒症AKI的早期诊断、病理生理、治疗方法、恢复和随访等方面进行阐述，以期提高脓毒症AKI在临床与基础方面的认识，降低脓毒症AKI的死亡率。“,”Sepsis is a life-threatening multiple organ dysfunction syndrome caused by infection, and kidney is one of the most organs susceptible to injury in sepsis. Critical ill patients with sepsis often suffer from acute kidney injury (AKI) of varying degrees with a high mortality. There are more and more researches on the early identification, pathogenesis, diagnosis and treatment of acute kidney injury in sepsis. In order to improve the understanding and reduce the mortality of acute kidney injury, this review briefly discussed the early identification, physio-pathologic mechanism, treatment, prognosis and follow up.