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目的观察缩宫素与罗哌卡因配伍用于术后硬膜外自控镇痛的效果。方法选择硬膜外阻滞剖宫产90例,随机分为3组,每组30例。A组为0.18%甲磺酸罗哌卡因,B组为10 U缩宫素+0.18%甲磺酸罗哌卡因,C组为对照组0.5%曲马朵+0.18%甲磺酸罗哌卡因,持续量2.0 ml/h,PCA为0.5 ml/15 min,记录24 h、48 h疼痛视觉模拟评分(VAS)、疼痛语言评分、PCA次数及产妇主观不适感。结果A、B、C 3组24 h VAS评分分别为(4.3±0.6)、(2.1±0.8)、(1.9±0.6);优良率(VAS<3)分别为23.3%(7/30例)、83.3%(25/30例)、86.7%(26/30例)。B组术后镇痛优良率明显优于A组(P<0.01),与C组镇痛效果相当(P>0.05)。结论缩宫素与甲磺酸罗哌卡因联合用于剖宫产术后硬膜外镇痛有良好的术后镇痛作用,其镇痛效果与曲马朵大体相当,不良反应小于曲马朵。
Objective To observe the effect of oxytocin combined with ropivacaine for postoperative epidural controlled analgesia. Methods 90 cases of epidural block cesarean section were randomly divided into 3 groups, 30 cases in each group. Group A was 0.18% ropivacaine mesylate, Group B was 10 U oxytocin + 0.18% ropivacaine mesylate, Group C was 0.5% tramadol + 0.18% ropivacaine mesylate in group C The continuous visual acuity score (VAS), pain language score, PCA frequency and maternal subjective discomfort were recorded. The continuous dose of CaCl2 was 2.0 ml / h and the PCA was 0.5 ml / 15 min. Results The VAS scores at 24 h in groups A, B and C were (4.3 ± 0.6), (2.1 ± 0.8) and (1.9 ± 0.6), respectively. The excellent and good rates were 23.3% (7/30) 83.3% (25/30 cases) and 86.7% (26/30 cases). The excellent and good rate of postoperative analgesia in group B was significantly better than that in group A (P <0.01), and the analgesic effect was similar in group C (P> 0.05). Conclusion Oxytocin combined with ropivacaine mesylate for postoperative epidural analgesia after cesarean section has a good postoperative analgesic effect, analgesic effect is generally equivalent to that of tramadol and adverse reactions are less than that of tramadol Duo