目的　使用静脉推注和区域性动脉灌注两种给药途径 ,研究表阿霉素在大鼠胰腺和血液中的分布。方法　经颈静脉推注表阿霉素或经髂外动脉插管至腹腔干动脉及肠系膜动脉 ,行胰腺区域性动脉灌注 ,剂量均为 7.5mg/kg体重。用高效液相色谱法测定血浆及胰腺组织中表阿霉素的含量。结果　区域性动脉灌注时 ,胰腺组织药物时量曲线下面积 (AUC)较静脉推注法提高49 .10 % ,而血浆中AUC也较静脉给药上升 2 1.6 9%。结论　与静脉推注法比较 ,区域性动脉灌注法可提高胰腺组织中表阿霉素的浓度 Objective To study the distribution of epirubicin in rat pancreas and blood using intravenous injection and regional arterial infusion. Methods Via injection of epirubicin via the jugular vein or cannulation via the external iliac artery to the celiac artery and the mesenteric artery, regional arterial perfusion of the pancreas was performed with doses of 7.5 mg / kg body weight. Determination of Epirubicin in Plasma and Pancreatic Tissues by High Performance Liquid Chromatography. Results During regional arterial infusion, the area under the curve of time-dose curve (AUC) of pancreatic tissue increased by 49.10% compared with intravenous bolus injection, while the plasma AUC also increased by 21.6% compared with intravenous injection. Conclusion Compared with intravenous injection method, regional arterial infusion method can increase the concentration of epirubicin in pancreatic tissue