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Objective:To observe the effect of Shenyi Capsule concomitant with Endosatr and chemotherapy in improving the proliferative activity and apoptosis of MCF-7 breast cancer cells. Methods:The cultured cells were randomly divided into control group, 5-Fu group, combination group 1, combination group 2 and combination group 3. The morphological changes were observed under inverted microscope, activity inhibition rate was calculated by methyl thiazolyl tetrazolium (MTT) method and lfuorescence microscope was applied to observe the apoptotic cells. Results: There were different degrees of morphological changes and functions of inhibiting cellactivity and improving apoptosis in each group except control group, which were the most signiifcant in combination group 3. Conclusion: Shenyi Capsule concomitant with endostar can be an optimal choice for the treatment of breast cancer.