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目的:探讨血清补体H因子在狼疮性肾炎发病中的作用及临床意义。方法:收集40例狼疮性肾炎、30例系统性红斑狼疮无临床肾脏损害者和30名健康献血员(对照组)的血清,采用间接酶联免疫吸附试验法检测H因子,分析H因子水平与狼疮性肾炎病理类型的关系。结果:狼疮性肾炎组和系统性红斑狼疮无临床肾脏损害组H因子水平低于对照组(P<0.01,P<0.05)。血清中H因子水平,狼疮性肾炎Ⅳ型低于Ⅱ型,差异有统计学意义(P<0.01),但Ⅳ型与Ⅲ型、Ⅲ型与Ⅱ型差异无统计学意义(P>0.05)。结论:H因子水平降低可能参与狼疮性肾炎的发病过程,且与狼疮性肾炎病理类型有关,与狼疮性肾炎肾脏损伤程度可能有关。
Objective: To investigate the role of serum complement factor H in the pathogenesis of lupus nephritis and its clinical significance. Methods: Serum of 40 cases of lupus nephritis, 30 cases of systemic lupus erythematosus without clinical kidney damage and 30 healthy blood donors (control group) were collected. The serum H level was measured by indirect enzyme - linked immunosorbent assay (ELISA) Relationship between pathological types of lupus nephritis. Results: The levels of H factor in lupus nephritis group and systemic lupus erythematosus without clinical renal impairment group were lower than those in control group (P <0.01, P <0.05). The level of H in serum and type Ⅳ of lupus nephritis were lower than those of type Ⅱ, the difference was statistically significant (P <0.01). However, there was no significant difference between type Ⅳ and type Ⅲ, type Ⅲ and type Ⅱ (P> 0.05). Conclusion: The decrease of H factor level may be involved in the pathogenesis of lupus nephritis and is related to the pathological type of lupus nephritis, which may be related to the degree of kidney damage in lupus nephritis.