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目的探讨支气管肺泡灌洗液肿瘤标记物检测在肺癌诊断中的应用。方法 2010年1月至2011年6月经组织学或细胞学明确诊断的肺癌患者70例为肺癌组,同期进行其他肺部疾病患者40例为对照组,观察两种方法肿瘤标记物检测。结果肿瘤组肺泡灌洗液肿瘤标记物检测值显著高于血清肿瘤标记物检测值,二者比较差异有统计学意义(P<0.05);肺泡灌洗液肿瘤标记物检测方法敏感性、特异性、诊断准确率明显优于血清肿瘤标记物检测。结论采取肺泡灌洗液进行肿瘤标记物检测对肺癌的诊断更具有特异性,敏感性更高,有更高的诊断价值。
Objective To investigate the application of bronchoalveolar lavage fluid tumor markers in the diagnosis of lung cancer. Methods From January 2010 to June 2011, 70 lung cancer patients diagnosed histologically or cytologically as lung cancer group and 40 patients with other lung disease disease as control group during the same period. Tumor markers were detected by two methods. Results The tumor markers of alveolar lavage fluid in the tumor group were significantly higher than those of the serum tumor markers (P <0.05), and the sensitivity and specificity of detecting the tumor marker in the bronchoalveolar lavage fluid , Diagnostic accuracy was significantly better than serum tumor markers detection. Conclusion The detection of tumor markers by using alveolar lavage fluid is more specific and sensitive to the diagnosis of lung cancer and has a higher diagnostic value.