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目的 :探讨盐敏感者心理应激时血浆血管紧张素Ⅱ (AngⅡ )、醛固酮 (ALD)和心钠素(ANP)浓度的变化。方法 :以 48名健康的男大学生为研究对象 ,用口服盐水法将其分为盐敏感组与盐不敏感组 ,用速算比赛使其产生心理应激 ,比较两组人群心理应激前后血压、血浆AngⅡ、ALD与ANP的浓度。结果 :48名血压正常的大学生中 ,盐敏感者 14人 ,非盐敏感者 3 4人 ;两组人群心理应激后血压、血浆AngⅡ与ALD浓度均较应激前增加 (P <0 0 5 ) ,且盐敏感者上述三项指标的增幅较非盐敏感者大 (P <0 0 5 ) ,但两组人群应激前后的血浆ANP浓度无明显改变 (P >0 0 5 )。结论 :盐敏感者心理应激所致的血压、血浆AngⅡ与ALD浓度的增加幅度较非盐敏感组大 ;盐敏感与精神紧张在高血压病的发病过程中可能存在交互作用。
Objective: To investigate the changes of plasma concentrations of angiotensin Ⅱ (Ang Ⅱ), aldosterone (ALD) and atrial natriuretic peptide (ANP) in salt sensitive patients under psychological stress. Methods: Forty eight healthy male college students were enrolled in this study. They were divided into salt-sensitive group and salt-insensitive group by oral saline method. Psychological stress was induced by rapid calculation. The blood pressure before and after psychological stress was compared between two groups. Plasma Ang Ⅱ, ALD and ANP concentrations. Results: Among 48 college students with normal blood pressure, 14 were salt-sensitive and 34 were non-salt-sensitive. Blood pressure, plasma AngⅡ and ALD concentrations were increased in both groups after stress (P <0.05 ), And the salt sensitivity of the above three indicators of increase than non-salt sensitive (P <0 05), but the two groups of people before and after stress plasma ANP concentration had no significant change (P> 0 05). CONCLUSIONS: The salt stress-induced increase in blood pressure, plasma AngⅡ and ALD concentrations is greater in salt-sensitive individuals than in salt-sensitive individuals. There may be an interaction between salt stress and stress in the pathogenesis of hypertension.