目的探讨不同方法治疗围绝经期子宫内膜单纯性增生的临床效果。方法 148例围绝经期子宫内膜单纯性增生患者,根据治疗方式不同分为A组和B组,各74例。A组口服避孕药联合孕激素治疗,B组予以左炔诺孕酮宫内缓释系统(ING-IUS)治疗,比较两组患者临床治疗效果以及不良反应发生情况。结果治疗4个月后,两组患者病理缓解率比较差异无统计学意义(P>0.05);治疗期间,两组异常出血率比较差异有统计学意义(P<0.05);两组患者均未见血栓形成以及肝功能和肾功能损伤等不良反应发生。结论口服避孕药联合孕激素与ING-IUS在治疗围绝经期子宫内膜单纯性增生方面临床效果相类似,临床治疗上应根据患者身体情况、服药依从性以及对药物不良反应耐受情况合理选取。 Objective To investigate the clinical effects of different methods in the treatment of peri-menopausal endometrial simple hyperplasia. Methods 148 cases of menopausal endometrial simple hyperplasia patients, according to the different treatment groups were divided into group A and group B, 74 cases in each. A group of oral contraceptives combined with progesterone treatment, B group levonorgestrel intrauterine system (ING-IUS) treatment, the clinical efficacy of the two groups were compared and the incidence of adverse reactions. Results After 4 months of treatment, there was no significant difference in pathological remission rate between the two groups (P> 0.05). There was significant difference between the two groups in the rate of abnormal bleeding during the treatment (P <0.05) See thrombosis and liver function and renal dysfunction and other adverse reactions occur. Conclusion Oral contraceptives combined with progesterone and ING-IUS in the treatment of peri-menopausal endometrial simple hyperplasia clinical effect is similar to the clinical treatment should be based on the patient’s physical condition, medication compliance and adverse drug reactions to the rational selection of tolerance .