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1例71岁女性患者因怀疑院内感染给予亚胺培南西司他丁钠0.5 g,1次/8 h静脉滴注。第3天,患者突然出现抽搐、角弓反张、牙关紧闭,伴意识欠清、喘憋,持续约2~3 min,未予处理自行缓解。约15 min后上述症状再现,1~2 min后自行恢复正常。约75 min及2 h后症状再发,持续时间为3~5 min,两次均给予地西泮及醒脑静。第4次发作后约50 min上述症状再次发作,给予苯巴比妥效果欠佳,换用丙戊酸钠400 mg静脉泵入。约1 h后患者安静入睡。次日停用亚胺培南西司他丁钠,改为拉氧头孢钠,患者未再出现抽搐。
A 71-year-old female patient received intravenous instillation of imipenem and cilastatin sodium 0.5 g once / 8 h for suspected nosocomial infection. The third day, the patient suddenly appeared convulsions, angle arch anti-Zhang, tingling closed, with lack of consciousness, wheezing, lasted about 2 ~ 3 min, without treatment to ease. About 15 min after the above symptoms, 1 to 2 minutes to return to normal on their own. About 75 min and 2 h after the recurrence of symptoms, the duration of 3 ~ 5 min, both were given diazepam and Xingnaojing. Approximately 50 minutes after the fourth attack, the above symptoms reoccurred, giving phenobarbital ineffective, switching to sodium valproate 400 mg intravenously. About 1 h after the patient fell asleep. Imidaclconazole cilastatin sodium was discontinued the next day and the drug was changed to cefoxitin sodium. No convulsions occurred in the patient.