硫代磷酸酯寡聚核苷酸(PS-ODN)是一类颇有应用前景的反义核酸,本文结合最新研究进展,就PS-ODN作为反义药物所需具备的条件和在抗病毒、抗肿瘤及遗传学分析和分子生物学研究中的应用作了较为详尽的论述。 Phosphorothioate oligonucleotide (PS-ODN) is a kind of quite promising antisense nucleic acids. In this paper, with the latest research progress, PS-ODN as an antisense drug has the necessary conditions and in the anti-virus, Antitumor and genetic analysis and molecular biology research made a more detailed discussion.