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目的探讨甲状腺乳头状癌中caveolin-1(cav-1)与pERK1/2的表达及其意义。方法采用免疫组织化学法,检测40例甲状腺乳头状癌、11例甲状腺腺瘤及10例癌旁正常甲状腺组织中cav-1和pERK1/2的表达,并分析表达情况与临床病理参数之间的关系。结果cav-1在甲状腺腺瘤和癌旁甲状腺组织中为低表达或无表达,而在甲状腺乳头状癌中呈高表达(阳性率为60%),且与肿瘤的包膜浸润和淋巴结转移相关。pERK1/2在甲状腺乳头状癌、甲状腺腺瘤和癌旁甲状腺组织中均见表达,三者差异无统计学意义。cav-1和pERK1/2两者之间的表达无相关性。结论cav-1高表达可能参与调控甲状腺乳头状癌的进展和转移,可作为预后不良的指标。
Objective To investigate the expression of caveolin-1 (cav-1) and pERK1 / 2 in papillary thyroid carcinoma and its significance. Methods Immunohistochemistry was used to detect the expression of cav-1 and pERK1 / 2 in 40 cases of thyroid papillary carcinoma, 11 cases of thyroid adenoma and 10 cases of adjacent normal thyroid tissue. The relationship between the expression and clinical pathological parameters relationship. Results The expression of cav-1 was low or no in thyroid adenoma and paracancer thyroid tissues, while it was highly expressed in thyroid papillary carcinoma (positive rate was 60%), which was correlated with tumor invasion and lymph node metastasis . pERK1 / 2 in thyroid papillary carcinoma, thyroid adenoma and parathyroid tissue were seen, the difference was not statistically significant. There was no correlation between the expression of cav-1 and pERK1 / 2. Conclusion Cav-1 overexpression may be involved in the regulation of papillary thyroid carcinoma progression and metastasis, which can be used as an indicator of poor prognosis.