白细胞介素IL-17是一种重要的炎症细胞因子,与炎症、肿瘤、过敏性疾病、自身免疫性疾病等的发生发展有着密切关系,在体内主要由CD4+T细胞(如Th17细胞)产生,也可由巨噬细胞、星形细胞、Langerhans细胞和肥大细胞分泌,其受体广泛表达于成纤维细胞、角化细胞、巨噬细胞、树突状细胞、内皮细胞、上皮细胞、软骨细胞及成骨细胞。因此,由 Interleukin-17 is an important inflammatory cytokine that is closely related to the occurrence and development of inflammation, tumor, allergic diseases, autoimmune diseases and the like, and is mainly produced by CD4 + T cells (such as Th17 cells) in vivo , But also by macrophages, astrocytes, Langerhans cells and mast cells, whose receptors are widely expressed in fibroblasts, keratinocytes, macrophages, dendritic cells, endothelial cells, epithelial cells, chondrocytes and osteoblast. Therefore, by