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观察酒精、洗衣粉、敌百虫日常使用浓度和１％浓度对皮肤屏障功能的影响。使用豚鼠的腹部皮肤，采用离体动式模型，以氚水的渗透速率作为评价屏障功能的指标。发现７５％、５０％酒精，１％洗衣粉增加了氚水的渗透速率（Ｐ＜０．０５）；同样１％浓度的这三种物质对皮肤屏障的影响以１％洗衣粉最大。提示从皮肤屏障的角度考虑，日常使用浓度的洗衣粉（０．１％～０．３％）和敌百虫（０．１％～０．２％）是安全的，７５％酒精作为消毒剂，对皮肤有影响，此时皮肤在短期内应避免接触有害的化学物质。
The effects of alcohol, detergent, trichlorfon on daily and 1% concentration on skin barrier function were observed. Using guinea pig abdominal skin, an in vitro kinetic model was used to assess the barrier function using the permeation rate of tritiated water. Found that 75%, 50% alcohol, 1% detergent increased the penetration rate of tritiated water (P <0.05); the same 1% concentration of these three substances on the skin barrier with 1% detergent the largest. Tip From a skin barrier point of view, daily use of detergents (0.1% to 0.3%) and trichlorfon (0.1% to 0.2%) are safe, with 75% alcohol as a disinfectant , Have an effect on the skin, the skin should avoid contact with harmful chemicals in the short term.