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患者女,66岁,白人。1968年10月出现散在的出血点和瘀斑,肝脾淋巴结不肿大,血小板6,000/mm~3,凝血时间正常,骨髓象发现巨核细胞增多,诊断为特发性血小板减少性紫癜。先后用强的松60mg/日,脾切除治疗,血小板暂时上升。后用硫唑嘌呤150mg/日治疗,血小板减少无改善。1年半后发现很多瘀斑及出血点,血小板8,000/mm~3,凝集法间接血小板抗体检查,血小板抗体4(+)。环磷酰胺100mg/日治疗4月,血小板不增加。1972年间歇静注长春新硷2mg,血小板暂时上升。 1974年出现嗜睡,头痛,多血症及严重下肢浮肿
Female patient, 66 years old, white. 1968 October scattered bleeding spots and ecchymosis, hepatosplenomegaly lymph nodes, platelets 6,000 / mm ~ 3, clotting time is normal, the bone marrow found that megakaryocytes increased, the diagnosis of idiopathic thrombocytopenic purpura. Has used prednisone 60mg / day, splenectomy treatment, a temporary increase in platelets. After azathioprine 150mg / day treatment, no improvement in thrombocytopenia. A year and a half later found a lot of ecchymosis and bleeding points, platelets 8,000 / mm ~ 3, agglutination indirect platelet antibody examination, platelet antibody 4 (+). Cyclophosphamide 100mg / day treatment in April, no increase in platelets. In 1972 intravenous injection of vincristine 2mg, platelets temporarily increased. 1974 drowsiness, headache, hyperlipidemia and severe lower extremity edema