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目的探讨抗NMDAR脑炎合并卵巢肿瘤患者的临床特点,诊断标准及治疗方法。从而总结出适用于妇科医生的相关诊疗方案,提高妇科医生对该病的认识,并指导对该病的诊治,改善患者预后。方法回顾性分析2013年12月至2015年12月首都医科大学宣武医院收治的抗NMDAR脑炎合并卵巢肿瘤的6例临床资料。分析该病临床特点,诊断方案及治疗方法,并进行归纳分析。结果抗NMDAR脑炎患者临床表现特异性较差,头颅MRI等缺乏特异性,脑脊液抗NMDAR抗体检测为诊断的关键。及时诊治,预后较好。结论该病诊治难度大,作为妇科医生要充分认知该疾病,能为妇科卵巢肿瘤筛查、诊断及治疗提供重要意见,同时也能给予及时手术干预,改善预后。
Objective To investigate the clinical features, diagnostic criteria and treatment of patients with anti-NMDAR encephalitis and ovarian cancer. Thus summed up the relevant treatment programs for gynecologists, gynecologists to improve awareness of the disease, and guide the diagnosis and treatment of the disease, improve patient prognosis. Methods The clinical data of 6 patients with anti-NMDAR encephalitis and ovarian cancer who were admitted to Xuanwu Hospital of Capital Medical University from December 2013 to December 2015 were retrospectively analyzed. Analysis of the clinical features of the disease, diagnostic programs and treatment methods, and conduct induction. Results The patients with anti-NMDAR encephalitis had poor specificity of the clinical manifestations and lack of specificity of cranial MRI. The detection of anti-NMDAR antibody in cerebrospinal fluid was the key to diagnosis. Timely diagnosis and treatment, the prognosis is good. Conclusion The diagnosis and treatment of this disease is very difficult. As a gynecologist, to fully understand the disease, it can provide important opinions for the screening, diagnosis and treatment of gynecologic ovarian tumors. At the same time, it can give timely surgical intervention and improve the prognosis.