青霉素G治疗钩体病常发生赫氏反应(JHR),可致肺弥漫性出血(PDH),应寻新药。鉴于国内尚无强力霉素治疗钩体病的报告,作者等于1987年探讨了强力霉素治疗钩体病。测青霉素G和强力霉素对临床分离的8株钩体抗菌活性(试管法)。选临床确诊,病程4日内,未用过抗菌药的感染中毒型钩体病34例(实验室证实30例,重型27例)随 Penicillin G treatment Leptospirosis often occur Herziation (JHR), can cause diffuse pulmonary hemorrhage (PDH), should find new drugs. In view of the fact that there is no report of treatment of leptospirosis with doxycycline in China, the authors discussed the treatment of leptospirosis with doxycycline in 1987. Eight strains of leptospira were isolated from clinical isolates of penicillin G and doxycycline and tested for antibacterial activity (in vitro method). Select the clinical diagnosis, the duration of 4 days, no antimicrobial agents infected leptospirosis in 34 cases (laboratory confirmed 30 cases, heavy 27 cases)