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目的探讨不同程度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血浆尾加压素Ⅱ(UⅡ)水平的变化,分析其在OSAHS发生发展中的作用。方法将2005年4月至2005年12月于温州医学院附属第一人民医院睡眠中心行多导睡眠(PSG)监测的鼾症患者60例分为单纯鼾症组和轻、中、重度OSAHS组,每组各15例。选取15名健康体检者为正常对照组。检测各组UⅡ水平,进行相关性分析。结果UⅡ水平正常对照组(1.14±0.65)ng/L、单纯鼾症组(1.37±0.42)ng/L、轻度OSAHS组(10.44±4.12)ng/L、中度OSAHS组(38.55±15.8)ng/L、重度OSAHS组(94.78±19.63)ng/L,单纯鼾症组与轻、中、重度OSAHS组两两比较,组间差异均有显著性意义(P<0.01)。结论UⅡ可能是参与OSAHS发生、发展的重要因素。
Objective To investigate the changes of urotensin Ⅱ (UⅡ) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and analyze its role in the development of OSAHS. Methods From April 2005 to December 2005, 60 patients with snoring who underwent polysomnography (PSG) sleep monitoring in the First People’s Hospital Affiliated to Wenzhou Medical College from April 2005 to December 2005 were divided into simple snoring group and mild, moderate and severe OSAHS group , Each group of 15 cases. Fifteen healthy people were selected as normal control group. The levels of UⅡ in each group were detected and the correlation analysis was carried out. Results The levels of UⅡ in normal OSAHS group (1.14 ± 0.65 ng / L), simple snoring group (1.37 ± 0.42) ng / L, mild OSAHS group (10.44 ± 4.12) ng / L and moderate OSAHS group (38.55 ± 15.8) ng / L, severe OSAHS group (94.78 ± 19.63) ng / L, there was significant difference between the simple snoring group and mild, moderate and severe OSAHS group (P <0.01). Conclusion U Ⅱ may be involved in the occurrence and development of OSAHS.