论文部分内容阅读
目的：为评价ＨＬＡＢ２７ 基因在强直性脊椎炎的临床诊断价值。方法：采用ＰＣＲＳＳＰ方法对１４１ 例风湿性病人，１６ 例强直性脊椎炎病人及４０ 例正常健康人ＨＬＡＢ２７ 基因检测， 并与血沉、影像学Ｘ 光片报告二项指标进行比较。结果：强直性脊椎炎病人组ＨＬＡＢ２７ 基因阳性率６８－８ ％ 与风湿性病人组ＨＬＡＢ２７ 基因阳性率１１－４％ 比较，Ｐ＜ ０－００５ ，有非常显著性差异；强直性脊椎炎病人Ｂ２７ 基因阳性率６８－８％ ，与血沉结果升高率８７－５ ％ 比较，Ｐ＞ ０－０５ ，无显著性差异；与Ｘ 光片结果阳性率２５－０％ 比较，０－０５ ＞ Ｐ＞ ０－０１ ，有显著性差异。结论：认为ＨＬＡＢ２７ 基因对强直性脊椎炎有一定早期诊断价值，并与血沉、Ｘ光片联合检测可提高诊断正确率。
Objective: To evaluate the clinical diagnostic value of HLA B27 gene in ankylosing spondylitis. Methods: PCRSSP method was used to detect HLAB27 gene in 141 rheumatic patients, 16 patients with ankylosing spondylitis and 40 normal healthy subjects, and compared with the indexes of ESR and radiography. Results: The positive rate of HLAB27 gene in patients with ankylosing spondylitis was 68-8%, while the positive rate of HLAB27 gene in rheumatoid patients was 11-4%, P <0-005. There was a significant difference between the two groups The positive rate of B27 gene in patients with inflammatory disease was 68-8%, which was not significantly different from that of 87.5% of patients with erythrocyte sedimentation rate (P> 0-05). The positive rate of B27 was 0-0 > P> 0-01, there are significant differences. Conclusion: HLA B27 gene has some early diagnostic value for ankylosing spondylitis, and combined with ESR and X-ray can improve the diagnostic accuracy.