论文部分内容阅读
目的 探讨血管紧张素Ⅱ受体拮抗剂Losartan(商品名科素亚 )对老年高血压病肾功能的影响。方法 采用前瞻性分析研究 ,5 2例老年高血压病患者随机分为 2组 :Losartan组 (2 6例 5 0mg每日 1次 ) ;贝那普利组(2 6例 10mg每日 1次 ) ,疗程 12周。观察治疗前后肾功能指标及血压的变化。 结果 Losartan能显著降低高血压 (P <0 0 1) ;明显减少尿蛋白的排汇量 :2 4小时尿白蛋白、2 4小时尿蛋白、血尿 β2 —微球蛋白均较治疗前明显下降 (P均 <0 0 1)。Losartan组与贝那普利组之间无显著性差异 (P >0 0 5 )。结论 Losartan单独治疗老年原发性高血压患者在有效降低高血压同时 ,具有减少蛋白尿 ,保护肾功能作用。
Objective To investigate the effect of Losartan, an angiotensin Ⅱ receptor antagonist, on renal function in elderly hypertensive patients. Methods Fifty-two elderly patients with essential hypertension were randomly divided into two groups: Losartan group (26 patients with 50 mg daily), and benazepril group (26 patients with 10 mg daily) , Treatment for 12 weeks. Changes of renal function and blood pressure before and after treatment were observed. Results Losartan significantly reduced hypertension (P <0.01), and significantly reduced urinary albumin excretion: 2-4 hours urinary albumin, 24 hours urinary protein and hematuria β2 - microglobulin were significantly lower than those before treatment P <0 0 1). There was no significant difference between Losartan group and benazepril group (P> 0.05). Conclusion Losartan alone treatment of elderly patients with essential hypertension in reducing hypertension, while reducing proteinuria, the role of renal protection.