论文部分内容阅读
近来常应用甲氰咪胍(Cimetidine)治疗食管返流,虽能改善烧心等症状,但内窥镜发现食管炎仍然存在。本文作者设计了二种鼠的实验模型:模型Ⅰ系将空肠第一段作食管-空肠吻合术,产生胆汁和酸返流;模型Ⅱ系先作全胃切除,然后将空肠与食管吻合,产生单独胆汁返流。实验鼠共50只。在模型Ⅰ的13只鼠和模型Ⅱ的11只鼠,每日二次皮下注射甲氰咪胍20mg,并随意饮含20mg/ml甲氰咪胍的水,共治疗30天。其余模型Ⅰ14只鼠、模型Ⅱ12只鼠不服药作为对照组。实验完结后,将死亡鼠的食管作标本照相和显微镜病理切
Cimetidine (Cimetidine) is often used to treat esophageal reflux, although it can improve the symptoms such as heartburn. However, endoscopic findings of esophagitis still exist. The authors designed two experimental models for rats: Model I used the first segment of the jejunum for esophageal-jejunal anastomosis resulting in bile and acid reflux; model II was first gastrectomy followed by anastomosis of the jejunum with the esophagus Bile reflux alone. A total of 50 mice. Thirteen rats in model I and 11 rats in model II were subcutaneously injected with 20 mg of cimetidine twice a day, and water of 20 mg / ml cimetidine was given at random for a total of 30 days. The rest of the model I14 rats, model Ⅱ 12 rats were not taking medicine as the control group. After the experiment was finished, the esophagus of the deceased mice was photographed and examined by microscopy