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目的:探讨牙周炎患者血清及龈沟液IL-8、TNF-α、IL-6、IL-21及骨代谢的变化规律。方法:选取2008年12月-2010年2月于我院进行治疗的60例牙周炎患者为研究对象,选取同期的60名健康人为对照组,分别检测其血清及龈沟液IL-8、TNF-α、IL-6、IL-21及血清骨钙素、碱性磷酸酶、总钙及磷的水平。结果:经研究比较发现,观察组的IL-8、TNF-α、IL-6、IL-21、总钙及磷均高于对照组,血清骨钙素、碱性磷酸酶低于对照组,经比较,P均<0.05,均有显著性差异。结论:牙周炎患者血清及龈沟液TNF-α、IL-8、TNF-α、IL-6、IL-21及骨代谢的变化较大,可从一定程度上反应疾病的情况,值得临床进一步研究及探讨。
Objective: To investigate the changes of serum and gingival crevicular fluid IL-8, TNF-α, IL-6, IL-21 and bone metabolism in patients with periodontitis. Methods: Sixty patients with periodontitis who were treated in our hospital from December 2008 to February 2010 were enrolled in this study. Sixty healthy subjects in the same period were selected as the control group. Serum and gingival crevicular fluid IL-8, TNF-α, IL-6, IL-21 and serum osteocalcin, alkaline phosphatase, total calcium and phosphorus levels. Results: Compared with the control group, the levels of IL-8, TNF-α, IL-6, IL-21, total calcium and phosphorus in the observation group were significantly lower than those in the control group After comparison, P <0.05, there are significant differences. CONCLUSIONS: The changes of TNF-α, IL-8, TNF-α, IL-6, IL-21 and bone metabolism in serum and gingival crevicular fluid of patients with periodontitis are quite variable, which can reflect the disease status to a certain extent, Further research and discussion.