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择期开胸手术病人５０例，术后病人主诉疼痛时随机分为两组，每组２５例。Ｌ组静脉注射哌ＬＡＳ１．８ｇ，Ｐ组肌肉注射哌啶５０ｍｇ，观察两组镇痛持续时间，统计镇痛优良率，测定注药前、注药后１、３、５小时的ＲＲ、ＨＲ、ＳＢＰ／ＤＢＰ和ＳｐＯ２及嗜睡、恶心、呕吐的例数。结果显示，两组镇痛优良率无显著差异（Ｐ＞０．０５），Ｌ组镇痛维持时间长于Ｐ组（Ｐ＜０．０５）。Ｐ组恶心、呕吐及嗜睡发生率多于Ｌ组（Ｐ＜０．０５）。两组注药后ＨＲ、ＲＲ、ＳＢＰ／ＤＢＰ有所下降，均于注药后３小时恢复到注药前水平，组内及组间比较无显著差异（Ｐ＞０．０５），提示ＬＡＳ可替代哌啶用于胸科术后镇痛，不仅持续时间长，且无呼吸抑制、恶心呕吐之副反应。
Elective thoracotomy patients 50 cases, postoperative patients complained of pain were randomly divided into two groups, 25 cases in each group. L group received intravenous injection of piperacillin LAS1.8g, P group intramuscular injection of piperidine 50mg, observed the duration of analgesia in both groups, the statistical analgesic rate of good and bad, before and after drug injection 1,3,5 hours RR, HR, SBP / DBP and SpO2 and drowsiness, nausea, vomiting cases. The results showed that there was no significant difference between the two groups in the rate of analgesia (P> 0.05). The duration of analgesia in L group was longer than that in P group (P <0.05). The incidence of nausea, vomiting and lethargy in group P was more than that in group L (P <0.05). The HR, RR and SBP / DBP of both groups decreased after injection, and all returned to the levels before injection within 3 hours after injection. There was no significant difference between the two groups (P> 0.05), suggesting that LAS Replacing piperadine for thoracic postoperative analgesia, not only for a long time, and no respiratory depression, nausea and vomiting of the side effects.