我们曾用阈下剂量的二亚硝基哌嗪作为起动剂,然后用硫酸镍作促癌剂,成功地诱发了大鼠鼻咽癌。为了解镍在实验大鼠体内,特别是在鼻咽部的分布,我们设计了本实验。 材料与方法 用25只雄性成年大鼠(体重约100g)分为实验组与对照组。 实验组:15只,除供给谷类与青饲料以外,每日从口腔内灌入1％硫酸镍溶液0.25ml,持续30天。停镍后第3天全部处死。 We have used subthreshold doses of dinitrosopiperazine as a trigger, and then used nickel sulfate as a carcinogen to successfully induce nasopharyngeal carcinoma in rats. To understand the distribution of nickel in experimental rats, especially in the nasopharynx, we designed this experiment. Materials and Methods Twenty-five male adult rats (weight about 100 g) were divided into experimental group and control group. In the experimental group, there were 15 animals. In addition to supplying cereals and green feed, 0.25 ml of a 1% nickel sulfate solution was poured into the oral cavity daily for 30 days. All were sacrificed on the third day after stopping the nickel.