【摘 要】
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At the beginning of the last century, Dr. William Coley introduced “Coley\'s toxin” to the scientific community after observing that a small number of patients with sarcoma with infections developed spontaneous tumor regression. “Coley\'s toxin” consi
【机 构】
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Department of Immunology,Tianjin Medical University Cancer Institute and Hospital,National Clinical
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At the beginning of the last century, Dr. William Coley introduced “Coley\'s toxin” to the scientific community after observing that a small number of patients with sarcoma with infections developed spontaneous tumor regression. “Coley\'s toxin” consisted of bacteria or bacterial products and achieved a durable response in a small group of patients with cancer, most of whom had inoperable sarcoma. However, this response was usually unpredictable because of the lack of understanding of the immune response at that time. Since then, researchers have continued to study the relationship between cancer and the host immune system, and the dis-covery of “Coley\'s toxin” marked the beginning of cancer immunotherapy1.
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