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目的:制备格列喹酮固体分散体并考察其体外溶出性。方法:以聚乙烯吡咯烷酮K30(PVP)、聚乙二醇6000(PEG)为载体,溶剂熔融法和溶剂法制备格列喹酮固体分散体,并与原料药比较体外溶出度。结果:载体比例越大,药物溶出愈快。载体为PVP所制固体分散体的体外溶出行为总体优于载体为PEG者。格列喹酮-PVP固体分散体(1∶7)10min内体外溶出度达到70%以上,优于格列喹酮原料药。结论:成功制备了格列喹酮固体分散体。
Objective: To prepare solid dispersion of gliquidone and investigate its in vitro dissolution. Methods: The solid dispersion of gliquidone was prepared by polyvinylpyrrolidone K30 (PVP), polyethylene glycol 6000 (PEG) as solvent, solvent melting method and solvent method. The dissolution rate in vitro was compared with the drug substance. Results: The larger the carrier ratio, the faster the drug is eluted. The in vitro dissolution behavior of the solid dispersion with PVP was better than that of the carrier with PEG. Gliquidone-PVP solid dispersion (1: 7) in 10min in vitro dissolution rate of more than 70%, better than gliquidone API. Conclusion: The solid dispersion of gliquidone was successfully prepared.