论文部分内容阅读
目的探讨氧化苦参碱(oxymatrineOMT)对急性坏死性胰腺炎大鼠血清TNF-a和IL-10的作用及其意义。方法选择标准Wistar大鼠96只,随机分为3组:假手术组(SOn=32)、急性坏死性胰腺炎组(ANPn=32)和急性坏死性胰腺炎+OMT处理组(ANP+OMTn=32),以牛磺胆酸钠复制急性坏死性胰腺炎大鼠模型,OMT用药方法为胰管内给予牛磺胆酸钠后15min腹腔内注射给药50mg/(kg·h),共3次。动态观察同组不同时间,不同组同时间的血清TNF-a和IL-10含量变化。结果在4、8、12h和16h的血清TNF-a和IL-10(ANP组IL-10除16h外),ANP组和ANP+OMT组均显著高于SO组(P<0.01/P<0.05),且在ANP和ANP+OMT组TNF-a随病程进展而升高(P<0.05),在ANP组IL-10水平随病程进展降低(P<0.05),而在ANP+OMT组IL-10水平随病程进展增高(P<0.05)。在相同时段TNF-a水平在ANP组显著高于ANP+OMT组(P<0.01),而IL-10水平(除4h组无差异外)ANP+OMT组显著高于ANP组(P<0.05/0.01)。结论TNF-a和IL-10参与了大鼠ANP的病理过程,OMT可减少促炎细胞因子TNF-a的产生,上调抗炎细胞因子IL-10的负调控作用,有助于减轻ANP时炎性细胞因子瀑布样级联反应。
Objective To investigate the effect and significance of oxymatrine OMT on serum TNF-a and IL-10 in rats with acute necrotizing pancreatitis. Methods A total of 96 standard Wistar rats were randomly divided into 3 groups: sham operation group (SOn=32), acute necrotizing pancreatitis group (ANPn=32) and acute necrotizing pancreatitis+OMT treatment group (ANP+OMTn= 32) A rat model of acute necrotizing pancreatitis was replicated with sodium taurocholate. OMT was administered intraperitoneally with sodium taurocholate administered intraperitoneally at 50 mg/(kg·h) 15 min after a total of 3 doses. Dynamic observation of serum TNF-a and IL-10 levels in the same group at different times, different groups at the same time. Results Serum TNF-a and IL-10 at 4th, 8th, 12th, and 16th hour (except 16h for ANP group IL-10), ANP group and ANP+OMT group were significantly higher than SO group (P<0.01/P<0.05). ) In the ANP and ANP+OMT groups, TNF-a increased with the progression of the disease (P<0.05). In the ANP group, the level of IL-10 decreased with the progression of the disease (P<0.05), while in the ANP+OMT group IL- 10 levels increased with progression of disease (P<0.05). The level of TNF-a was significantly higher in the ANP group than in the ANP+OMT group (P<0.01), while the IL-10 level (except for the 4h group) was significantly higher in the ANP+OMT group than in the ANP group (P<0.05/ 0.01). Conclusion TNF-a and IL-10 are involved in the pathological process of ANP in rats. OMT can reduce the production of pro-inflammatory cytokine TNF-a, upregulate the negative regulation of anti-inflammatory cytokine IL-10, and help reduce ANP inflammation. Spontaneous cytokine cascade cascade reaction.