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目的:提高对恶性腹膜间皮瘤的认识和治疗水平。方法:回顾我院15年来收治8例恶性腹膜间皮瘤患者的临床资料,结合相关文献进行分析。结果:8例中术前确诊1例,行减瘤手术+腹腔及全身化疗;剖腹探查7例,其中6例行部分病灶切除+腹腔或/和全身化疗;1例行腹腔及全身化疗;8例均配合腹腔温热灌注。随访7例,半年内死亡1例,2 a内死亡5例,1例生存超过2 a。结论:恶性腹膜间皮瘤恶性程度高,临床无特异表现,诊断困难,易误诊,预后差。主要依靠剖腹探查、腹水脱落细胞检查、腹腔穿刺活检及腹腔镜等诊断。尽早实施减瘤术+腹腔及全身化疗能提高生存率。
Objective: To improve the understanding and treatment of malignant peritoneal mesothelioma. Methods: We retrospectively reviewed the clinical data of 8 patients with malignant peritoneal mesothelioma treated in our hospital for 15 years and analyzed the relevant literature. RESULTS: One of 8 cases was diagnosed preoperatively, followed by cytoreductive surgery + intraperitoneal and systemic chemotherapy; 7 cases were examined by laparotomy, of which 6 were performed with partial resection + peritoneal or/and systemic chemotherapy; 1 patient received abdominal and systemic chemotherapy; 8 The cases were all combined with warm intraperitoneal perfusion. Seven patients were followed up, 1 died within half a year, 5 died within 2 years, and 1 survived more than 2 months. Conclusion: Malignant peritoneal mesothelioma has high malignancy, no clinical manifestation, difficult diagnosis, misdiagnosis, and poor prognosis. Mainly rely on exploratory laparotomy, ascites exfoliated cell examination, abdominal biopsy and laparoscopic diagnosis. Early implementation of cytoreductive surgery + intraperitoneal and systemic chemotherapy can improve survival.