中药内服或外用、西药内服或腔内注射配合推拿治疗膝骨关节炎(knee osteoarthritis, KOA)，均可改善患者临床症状，提高患者生活质量。临床中辨证运用中药汤剂，结合理筋活络、通利关节类手法治疗本病，效果显著。而中药外治法不良反应少、操作便捷、经济实惠，应用亦较为广泛。临床应根据病情发展的不同阶段，制定适宜的治疗方案。目前推拿结合药物治疗KOA的研究大多集中在减少炎性细胞浸润上，对软骨细胞破坏的研究较少，可在手法对软骨细胞功能的影响、软骨的保护机制等方面进一步探索。“,”The clinical symptoms and quality of life of patients with knee osteoarthritis (KOA) can be improved by orally or externally use of TCM, as well as oral or intraluminal injection of western medicine combined with massage. In clinical practice, TCM decoction combined with massage manipulation, which tendons regulation, activating collaterals and joint activation could be used to treat KOA, and the curative effect is remarkable. The external treatment of TCM has the advantages of less adverse reactions, convenient operation, low cost and wide application. In clinical treatment, we should choose the appropriate treatment plan according to different stages of disease. At present, the research of massage combined with drug treatment of KOA mostly focuses on reducing the infiltration of inflammatory cells, and the still lacks related research on the destruction of chondrocytes. Further research on the effects of massage on the function of chondrocytes and the mechanism of cartilage protection is needed.