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目的:比较头孢呋辛不同时间给药对产妇剖宫产围术期预防术后感染的效果。方法:选取2013年9月—2016年6月期间收治的需剖宫产产妇174例,将其分为A组和B两组,每组87例;两组产妇均给予头孢呋辛预防剖宫产术后感染,A组产妇用药时间为术前0.5 h或结扎脐带后或术后24 h内给药,B组产妇用药时间为术后大于24 h给药,比较两组产妇剖宫产手术切口愈合情况、平均体温和术后1周内外周血白细胞计数(WBC)值。结果:两组产妇剖宫产手术切口甲级愈合率、感染率以及脂肪液化与伤口裂开率经组间比较其差异无统计学意义(P>0.05),术后平均体温值经组间比较其差异也无统计学意义(P>0.05);但A组产妇术后1周内的WBC值正常率明显高于B组(P<0.05),产妇的WBC值>10×109/L比例、平均WBC值均明显低于B组(P<0.05)。结论:头孢呋辛术前0.5 h和术后24 h内给药预防剖宫产术后伤口感染的效果优于术后大于24 h给药。
OBJECTIVE: To compare the effects of cefuroxime in different periods on postoperative infection prevention during cesarean section perinatal period. Methods: Seventy-four cases of cesarean section were selected from September 2013 to June 2016. They were divided into group A and group B, with 87 cases in each group. Both groups were given cefuroxime prophylaxis cesarean section Postoperative infection, group A maternal medication for 0.5 h before or after ligation of the umbilical cord or within 24 h after administration, B group maternal medication for more than 24 h after administration, compared the two groups of maternal cesarean section Incision healing, mean body temperature, and peripheral white blood cell count (WBC) values within 1 week after surgery. Results: There was no significant difference in grade A healing rate, infection rate, fat liquefaction and wound rupture rate between the two groups (P> 0.05). The average body temperature after the operation was compared between groups (P> 0.05). However, the normal rate of WBC in group A within one week after operation was significantly higher than that in group B (P <0.05). The WBC value of maternal group was> 10 × 109 / L, and the difference was not statistically significant Mean WBC values were significantly lower than those in group B (P <0.05). Conclusion: The effect of cefuroxime on the prevention of wound infection after cesarean section at 0.5 h and 24 h after operation is superior to that of cefuroxime at 24 h after operation.