目的 :观察脓毒血症时大鼠肾脏Ｇｑ/1 1蛋白的变化。方法 :采用盲肠结扎穿孔法复制大鼠腹膜炎脓毒血症模型 ,免疫印迹法测定大鼠肾Ｇｑ/1 1蛋白的含量。结果 :早期脓毒血症时肾脏Ｇｑ/1 1蛋白的含量无明显变化 ,晚期脓毒血症肾脏Ｇｑ/1 1的含量与对照组比较 1 45 6%± 1 6 48% Objective: To observe the change of Gq / 1 1 protein in rat kidney during sepsis. Methods: The cecal peritonitis sepsis model was replicated by cecal ligation and perforation, and the content of Gq / 1 1 protein in rat kidneys was determined by immunoblotting. Results: There was no significant change in the content of Gq / 1 1 protein in the early stage of sepsis. The level of Gq / 1 1 in the kidney of the late stage sepsis was 1 45 6% ± 1 6 48%