T细胞免疫球蛋白黏蛋白(T-cell immunoglobulin and mucin,TIM)基因被发现表达于小鼠染色体11B1.1。TIM分子广泛存在于多种免疫细胞特别是抗原呈递细胞表面,可参与天然免疫和获得性免疫;某些TIM分子存在着多种配体,对T细胞具有双重作用;TIM的异常表达与多种疾病发生有关,可能作为药物治疗的新靶点;TIM与调节性T细胞(Tregs)相关性研究为移植免疫耐受诱导提供了新思路。因此,本文就TIM家族成员的免疫调节功能作一综述。 T-cell immunoglobulin mucin (TIM) gene was found to be expressed on mouse chromosome 11B1.1. TIM molecules are widely present on the surface of many kinds of immune cells, especially antigen-presenting cells and may participate in natural immunity and adaptive immunity. Some TIM molecules have multiple ligands and have dual roles in T cells. The abnormal expression of TIM is associated with multiple It may be used as a new target of drug therapy. The study on the relationship between TIM and Tregs provides a new idea for the induction of immune tolerance. Therefore, this article reviews the immunomodulatory functions of TIM family members.