转化生长因子βⅡ型受体基因突变是某些肿瘤细胞逃逸转化生长因子β生长抑制调控的机制之一，有报道表明突变热点为其cDNA709－718的poly（A）10。为探讨转化生长因子βⅡ型受体基因突变与肝细胞癌的关系，我们应用PCR－SSCP银染法对28例肝癌组织和10例正常肝组织进行了检测，结果发现肝细胞癌组中有6例发生了突变，突变率为21．4％（6/28），正常肝组织中无此位点的突变。这提示转化生长因子闯型受体的突变在肝细胞癌的发生过程中起着重要作用。 Mutation of transforming growth factor-β type II receptor is one of the mechanisms of the growth inhibition of transforming growth factor β in some tumor cells. It has been reported that the mutation hotspot is poly(A)10 of cDNA 709-718. To investigate the relationship between TGF-βII receptor gene mutations and hepatocellular carcinoma, we detected 28 liver cancer tissues and 10 normal liver tissues using PCR-SSCP silver staining and found that there were 6 in the hepatocellular carcinoma group. There was a mutation in the case, the mutation rate was 21.4% (6/28), and there was no mutation in this site in normal liver tissue. This suggests that mutations in transforming growth factor 闯-type receptors play an important role in the development of hepatocellular carcinoma.