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本文介绍了1981年～1982年6月用放射免疫双抗体法测定120例癫痫儿童血苯妥英钠(DPH)浓度的结果。并对58例同时进行了均相酶免疫方法测定以对照。结果证实临床疗效与血DPH浓度有密切关系。提出DPH有效血浓度以5～20μg/ml为适宜。相应的给药剂量是1.0～7.7mg/kg/日。提出防治儿童癫痫,DPH有效剂量是2～8mg/kg/日。合用苯巴比妥时影响DPH血浓度。
This article describes the results of a radioimmunoassay assay of hemophile sodium (DPH) concentrations in 120 epileptic children from 1981 to 1982. 58 cases of simultaneous homogeneous enzyme immunoassay method for the control. The results confirm the clinical efficacy and blood levels of DPH are closely related. Proposed DPH effective blood concentration to 5 ~ 20μg / ml is appropriate. The corresponding dose is 1.0-7.7 mg / kg / day. Proposed prevention and treatment of childhood epilepsy, DPH effective dose is 2 ~ 8mg / kg / day. Combined phenobarbital affect DPH blood concentration.