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目的:评价氟康唑与克霉唑阴道片联用对白假丝酵母菌阴道炎患者的疗效与安全性。方法:选取2015年1月—2016年7月间收治的白假丝酵母菌阴道炎患者81例临床资料,按入院顺序编号采用随机数表法将其分为对照组(n=40)和观察组(n=41);对照组患者给予单用克霉唑阴道片治疗,观察组患者在对照组基础上加用氟康唑治疗,评价两组患者治疗后的总有效率和不良反应发生的变化情况。结果:观察组患者治疗后的总有效率为95.12%高于对照组为75.00%(P<0.05);两组患者用药期间不良反应的发生率经组间比较其差异无统计学意义(P>0.05),而观察组患者阴道炎的复发率为4.89%低于对照组为25.00%(P<0.05)。结论:采用氟康唑与克霉唑阴道片联用治疗白假丝酵母菌阴道炎患者的疗效优于单用克霉唑阴道片的治疗,且“安全性好、不易复发”等优势。
Objective: To evaluate the efficacy and safety of fluconazole and clotrimazole vaginal tablets in patients with Candida albicans vaginitis. Methods: The clinical data of 81 cases of Candida albicans vaginitis admitted from January 2015 to July 2016 were randomly divided into control group (n = 40) and observation group (N = 41). The patients in the control group were treated with clotrimazole vaginal tablets alone. The patients in the observation group were treated with fluconazole on the basis of the control group. The total effective rate and the adverse reactions after treatment were evaluated Changes. Results: The total effective rate after treatment in the observation group was 95.12%, which was significantly higher than that in the control group (75.00%, P <0.05). There was no significant difference in the incidence of adverse reactions between two groups (P> 0.05). However, the recurrence rate of vaginitis in the observation group was 4.89% lower than that in the control group (25.00%, P <0.05). Conclusion: The efficacy of combination of fluconazole and clotrimazole vaginal tablets in the treatment of patients with C. albicans vaginitis is superior to the treatment with clotrimazole vaginal tablets alone, and the advantages of “safe, difficult to relapse” .