慢心律(Mexiletine)为第一类抗心律失常药,最初用于抗惊厥。1968年有人发现它与苯妥英钠一样有抗心律失常作用。自从1969年慢心律用于治疗心律失常以来,国内外已对其药理学(药效学与药代动力学)和临床应用作了进一步的研究,现综述如下。一、药效学慢心律的化学结构和利多卡因相似,与利多卡因一样有局部麻醉、抗惊厥和抗心律失常作用。Danneberg 等发现,在局部麻醉作用方面,慢心律和利多卡因、可卡因或心得安的效果相同;在抗惊厥作用方面,它可抑制电刺激猫扁桃核产生的 Mexiletine is the first anti-arrhythmic drug, originally used for anticonvulsant. It was found in 1968 that it had the same anti-arrhythmic effect as phenytoin. Since 1929, slow heart rhythm for the treatment of arrhythmia, both at home and abroad have its pharmacology (pharmacodynamics and pharmacokinetics) and clinical application made further research, are summarized below. Pharmacodynamics Slow rhythm of the chemical structure and lidocaine similar lidocaine and local anesthesia, anticonvulsant and anti-arrhythmic effect. Danneberg et al. Found that slow-acting rhythm and lidocaine, cocaine or propranolol have the same effect on local anesthesia. In anticonvulsant effect, it can inhibit the electrical stimulation of the cat’s amygdala